Sangyu Xu 徐摑榆
  • Home
  • Statistics
  • Neuroscience
  • Genetic Tools
  • LLM Evals
  • Writing
  • Art & Music
  • CV
  • xusangyu.com

CV

Curriculum Vitae

Selected Publications Google Scholar β†—

Lu Z*, Anns J*, Mai Y*, Xu S*† et al. Getting over ANOVA: Estimation graphics for multi-group comparisons. (co-corresponding, in revision). bioRxiv 2026.
Xu S et al. Contextualized ethomics reveals a Drosophila serotonergic circuit controlling satiety. (in revision).
Xu S†, Das G, Hueske E, Tonegawa S†. Dorsal raphe serotonergic neurons control intertemporal choice under trade-off. Current Biology 2017; 27(22):3440–3451. (Co-corresponding; 48 citations.)
Zhang X, Xu S, Ho J, Stewart JC, Claridge-Chang A. A mushroom-body output neuron that mediates octopamine-driven and hunger-motivated feeding in Drosophila. bioRxiv 2026.
Ott S, Xu S, Lee N, Hong I, Anns J, et al. Kalium channelrhodopsins effectively inhibit neurons. Nature Communications 2024; 15:3480.
Xu S, Zhang X, Cheung KY, Mai Y, Wu Y, Claridge-Chang A. Long-Stokes-Shift mScarlet3 as a structural marker for two-photon imaging. bioRxiv 2026.
Bari A, Xu S et al. Differential attentional control mechanisms by two distinct noradrenergic pathways. PNAS 2020; 117(46):29080–29089. (119 citations.)
Kim J, ..., Xu S, Tonegawa S. Antagonistic negative and positive neurons of the basolateral amygdala. Nature Neuroscience 2016; 19(12):1636–1646. (550 citations.)

Experience

Senior Research Fellow β€” Duke-NUS Medical School Singapore 2026–present

Computational ethomics for internal state detection. Epitranscriptomics of native RNA states.

Senior Research Fellow / Research Fellow β€” IMCB, A*STAR Singapore 2017–2026

Automatic behavior tracking. Estimation statistics. Computational ethomics. Epitranscriptomics of native RNA states.

Postdoctoral Associate β€” Tonegawa Lab, MIT 2016–2017

Characterised serotonergic control of intertemporal choice in mice (Current Biology 2017).

Education

PhD Systems Neuroscience β€” MIT 2016

Supervisor: Susumu Tonegawa. Dissertation: Control of intertemporal choice by dorsal raphe serotonergic neurons.

BS Biology (Minor: Music) β€” UC San Diego 2007

Supervisor: Charles Zuker. Undergraduate Dissertation: A Novel Trans-Synaptic Neuronal Tracing Strategy.

Technical Skills

Python R Git nbdev Quarto pandas NumPy SciPy PyTorch matplotlib LLM-as-Judge DSPy LangGraph Claude API agentic evals adversarial red-teaming prompt engineering bootstrap CI effect size estimation uncertainty quantification causal inference A/B testing experimental design Oxford Nanopore direct RNA-seq epitranscriptomics DeepLabCut SLEAP SQL

Recognition

Outstanding Short Talk Award β€” Neuroscience Singapore 2025
Gold Medal β€” 17th International Festival of Advent and Christmas Music, Prague, 2007
Honourable Mention β€” Singapore Physics Olympiad, 2002

Teaching

GMS6812 Modern Data Analysis for Biomedical Research (Teaching Assistant) Duke-NUS, Feb 2023
Evidence Session: Modern Data Analysis for Biomedical Research (Teaching Assistant) Duke-NUS, Oct 2022
YSC4229 Molecular Neuroscience – Genes, Brains, and Behaviour (Guest Lecturer) Yale-NUS, March 2023
GMS6812 Modern Data Analysis for Biomedical Research (Teaching Assistant) Duke-NUS, Feb 2022
Evidence Session: Modern Data Analysis for Biomedical Research (Teaching Assistant) Duke-NUS, Oct 2021
YSC4229 Molecular Neuroscience – Genes, Brains, and Behaviour (Guest Lecturer) Yale-NUS, March 2021
9.013 Molecular and Cellular Neuroscience II (Graduate) MIT, Spring 2011
9.301 Neural Plasticity in Learning and Memory (Graduate) MIT, Spring 2010
9.150 Biochemistry and Pharmacology of Synaptic Transmission (Undergraduate) MIT, Fall 2009
Walle Nauta Award for Excellence in Graduate Teaching β€” MIT, 2011

Service

Society for Neuroscience, Singapore Chapter (Treasurer) Singapore, 2021–2024
Society for Neuroscience, Singapore Chapter (Director of Membership) Singapore, 2018–2020

Media Coverage

Duke-NUS researchers develop light-controlled β€˜switch’ for brain cells to better study the brain. The Straits Times (July 15, 2024).
Two Distinct Ways the Brain Stays Focused and Curbs Impulses. Psychology Today (November 6, 2020).
A delicate balance between positive and negative emotion. MIT Press (October 17, 2016).

Arts

Painter β€” 22nd UOB Painting of the Year Exhibition, Singapore, 2003
Ceramicist β€” The Art of the Cup, Cambridge, MA, USA, 2014